GPI-1046 is a non-immunosuppressive immunophilin ligand used in research for its neuroprotective effects. It has been reported to upregulate glutamate transporter 1 (GLT1), reduce ethanol intake, and attenuate HIV-associated sensory neuropathy by modulating store-operated calcium entry. The compound is provided as a high-purity liquid (formula C20H28N2O4, MW ~360.45 g/mol).
- Non-immunosuppressive immunophilin ligand
- Reported neuroprotective activity
- Upregulates glutamate transporter 1 (GLT1)
- Attenuates HIV-associated sensory neuropathy via store-operated calcium entry modulation
- High purity (≈99.8%)
- Liquid appearance: colorless to light yellow
- Chemical formula C20H28N2O4; molecular weight ~360.45 g/mol
- Storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month)